Spasticity Trials Review
GW Sativex MS Trials
GW has sponsored clinical trials studying the effect of Sativex on symptoms of MS including; spasticity, neuropathic pain and bladder control. In all of these trials, patients remained on their existing medication during the course of the trial. All symptom relief obtained from Sativex in these trials was over and above any effect achieved by the patients' existing treatments.
All completed trials for the spasticity indication are listed below, together with associated publications and/or press releases where available. If you are a prescriber and would like information on other MS related trials, please click here.
Michael G. Serpell, William Notcutt, Christine Collin. J Neurol 2013;260:285-295.
A placebo-controlled, parallel-group, randomized withdrawal study of subjects with symptoms of spasticity due to multiple sclerosis who are receiving long-term Sativex® (nabiximols).
Notcutt W, Langford R, Davies P, Ratcliffe S, Potts R. Mult Scler. 2012 Feb;18(2):219-28. Epub 2011 Aug 30.
A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex® ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis.
Novotna A, Mares J, Ratcliffe S, Novakova I, Vachova M, Zapletalova O, Gasperini C, Pozzilli C, Cefaro L, Comi G, Rossi P, Ambler Z, Stelmasiak Z, Erdmann A, Montalban X, Klimek A, Davies P; Sativex Spasticity Study Group. Eur J Neurol. 2011 Sep;18(9):1122-31
A double-blind, randomised, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis.
Collin C, Ehler E, Waberzinek G, Alsindi Z, Davies P, Powell K, Notcutt W, O'Leary C, Ratcliffe S, Nováková I, Zapletalova O, Piková J, Ambler Z. Neurological Research, 2010; 32(5), 451-459
Collin C, Davies P, Mutiboko IK, Ratcliffe S. European Journal of Neurology. 2007;14:290-6.
Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis.
Wade DT, Makela PM, House H, Bateman C, Robson P. Mult Scler. 2006 Oct;12(5):639-45.
Sativex: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain.
Barnes MP. Expert Opin Pharmacother. 2006 Apr;7(5):607-15.